Telos Biotech
Telos Biotech Inc.
Telos Biotech is a biotechnology startup that develops technologies to enhance the manufacturing of cell therapies. The company, launched by Cambrian Bio in 2022, focuses on addressing telomere shortening during cell expansion to improve the function, longevity, and robustness of therapeutic cells used to treat cancer and age-related diseases.
Products & Team
Telovance™
Telovance™ is a proprietary protein complex delivered during the ex-vivo cell expansion phase of manufacturing. It works by rapidly and safely lengthening the shortest telomeres within the therapeutic cells, without the risks associated with constitutive telomerase expression.
It solves the critical manufacturing challenge of telomere attrition, which occurs during the rapid cell expansion required to produce a therapeutic dose. This attrition limits the persistence and effectiveness of the final cell product, and Telovance™ overcomes this limitation.
Customers face significant limitations in cell therapy manufacturing, including loss of cell fitness, reduced proliferative capacity, and premature cellular aging (senescence) due to telomere shortening during necessary ex-vivo expansion.