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Porosome Therapeutics

1 viewer · 30d

Total raised

$3.6M

1 filing since 2023 · latest Equity filed

Cumulative raised
LAST ROUND
Equity · $3.6M
ROUNDS
1
INVESTORS
7
FOUNDED
2021
HQ
Boston, MA
SECTOR
Biotech
EMPLOYEES
N/A
30D VIEWERS
1

AI overview

Updated

Porosome Therapeutics is a Boston-based preclinical biopharmaceutical company built around the porosome, the cell's universal secretory machinery. It develops therapies that either reconstitute functional porosomes into diseased cells or target previously undruggable porosome proteins with small molecules and peptides. Its programs span Alzheimer's disease, cystic fibrosis, type 1 and type 2 diabetes, and lung cancer, and it received FDA orphan drug designation for its cystic fibrosis program in 2025. AI-driven small molecule discovery runs through its Porosome.AI LLC subsidiary and the Alzheimer's work through its NeuroTher LLC subsidiary.

What sets it apart

The first company to build a drug discovery platform dedicated to the porosome, opening a target class treated as undruggable and letting one mechanism address diseases as different as Alzheimer's, cystic fibrosis and diabetes.

Funding history

1 round
EquitySep 8, 2023 · $50K min
Form D/A
+$3.6M$3.6M total

Latest SEC filings

via EDGAR · CIK 0001934919
Form D/A · Sep 8, 2023View on EDGAR

Products

1 tracked

Porosome reconstitution therapy

Preclinical therapeutic platform

A first-in-class, disease-modifying biologic approach that introduces functional porosomes into the plasma membrane of diseased cells to restore normal secretion, combined in the lead program with a small-molecule flavonoid.

  • Restores secretion by reconstituting the cell's native secretory machinery
  • Preclinical evidence in Alzheimer's human brain organoids, including Tau reduction
  • Cystic fibrosis program reported restoring mucin secretion more effectively than TRIKAFTA in assays, with FDA orphan drug designation in 2025
  • Diabetes program targets insulin secretory defects in stem cell derived beta cells

Links

WebsiteSEC EDGAR filings