QTX3034
Clinical-stage oncology drug candidate
An oral, G12D-preferring multi-KRAS allosteric inhibitor in Phase 1 dose expansion, studied as monotherapy and in combination with cetuximab and chemotherapy in pancreatic, colorectal and endometrial cancers.
- Oral small molecule
- Allosteric, conformational blockade mechanism
- G12D-preferring with multi-KRAS activity
- Phase 1 dose expansion across three tumor types
- Combination arms with cetuximab and chemotherapy
- CNS penetration potential
Built for
Oncologists and patients with RAS-driven solid tumors — pancreatic, colorectal and endometrial cancer — plus pharmaceutical partners for RAS programs