Funded Biotech startups in California
64 biotech startups in California have filed a Form D with the SEC and together report $1.84B raised. NGM Bio has the largest latest round, at $142M. Amounts are as reported on the filing, not estimates.
Updated Sep 15, 2026
- Companies
- 64
- Total raised
- $1.84B
- Filings
- 102
- Median round
- $6.7M
- Cities
- 32
CompanyCityLast filingLatest round
Tempest TherapeuticsIn vivo CAR-T therapies for autoimmune disease and cancer
Brisbane
Sep 15, 2026
$7.5M
Caspian TherapeuticsMenin inhibitors to restore insulin production
San Diego
Sep 8, 2026
$50.0M
Integrated BiosciencesSmall-molecule drugs for aging and cardiometabolic disease
Redwood City
Jul 21, 2026
$68.4M
Jasper TherapeuticsAntibody drugs for chronic hives and rare immune diseases
Redwood City
Jul 21, 2026
$132.0M
Mangrove TherapeuticsTherapies targeting an RNA regulator of inflammation
Sacramento
Jul 21, 2026
$2.5M
Oncotelic TherapeuticsAntisense RNA drugs for cancer and viral disease
Agoura Hills
Jul 10, 2026
$712K
AmlogenyxGene therapy that clears amyloid in Alzheimer's disease
Novato
Jul 1, 2026
$10.0M
ImmunoVecDNA medicines that engineer immune cells inside the body
Los Angeles
Jun 29, 2026
$12.7M
Rapalogix HealthProfessional longevity skincare sold through dermatologists
Carlsbad
Jun 22, 2026
$19.1M
AcuraStemAntisense drugs for ALS and frontotemporal dementia
Pasadena
Jun 18, 2026
N/A
Lycia TherapeuticsExtracellular protein degraders for immune diseases
South San Francisco
Jun 10, 2026
$75.0M
NeOnc TechnologiesIntranasal perillyl alcohol for brain tumors
Westlake Village
Jun 10, 2026
$5.0M
Reservoir NeuroscienceDrugs that repair the blood-brain barrier in aging
San Francisco
Jun 8, 2026
$3.0M
SonoTheraUltrasound-delivered gene therapies without viral vectors
South San Francisco
Jun 8, 2026
$125.5M
Rejuvenate BioGene therapies for age-related disease in dogs and people
San Diego
Jun 3, 2026
$19.5M
ImmunisStem cell secretome biologic for age-related muscle loss
Irvine
May 28, 2026
$12.0M
Antlia BioscienceLong-acting peptide therapy for chronic heart failure
Encinitas
May 22, 2026
$6.0M
Cognos TherapeuticsImplantable pump that delivers drugs into the brain
Inglewood
May 21, 2026
$250K
Senti BiosciencesGene medicines whose dose can be tuned after treatment
South San Francisco
May 20, 2026
$10.0M
Quince TherapeuticsDrugs encapsulated in a patient's own red blood cells
South San Francisco
May 18, 2026
N/A
Restora MedicalInnovative biotechnology company founded in 2023 and based in…
Irvine
May 18, 2026
$11.5M
ThinkBio.AiDrug success scoring from a biomedical knowledge graph
Ontario
May 18, 2026
N/A
AdelaMethylation blood tests for cancer monitoring
Foster City
Apr 10, 2026
$5.0M
Terremoto BiosciencesSelective AKT1 inhibitors for breast cancer and solid tumors
South San Francisco
Apr 10, 2026
$40.7M
TetrousBone fiber implants for tendon-to-bone repair
Sherman Oaks
Apr 8, 2026
$1.7M
Iambic TherapeuticsAI drug design with automated synthesis and testing
San Diego
Apr 1, 2026
$27.8M
Artelo BiosciencesLipid-signaling drugs for cachexia, pain and anxiety
Solana Beach
Mar 27, 2026
$11.0M
Valius SciencesMulti-omic tumor profiling for hard-to-treat cancers
San Francisco
Mar 25, 2026
$9.7M
Alume BiosciencesPeptide dye that makes nerves glow during surgery
La Jolla
Mar 24, 2026
$2.2M
RenovoRxIntra-arterial chemotherapy delivery for pancreatic cancer
Mountain View
Mar 20, 2026
$10.0M
Reprogram BiosciencesTumor-injected mRNA that reprograms cancer cells
San Carlos
Mar 16, 2026
$5.0M
Olden LabsAI smart cages that monitor lab rodents around the clock
South San Francisco
Mar 13, 2026
$6.5M
AtomwiseAI virtual screening for small-molecule drugs
San Francisco
Mar 10, 2026
$19.8M
Parcel BiosciencesNanoparticle-free mRNA delivery to specific cells
San Francisco
Feb 6, 2026
$13.2M
Trellis BioscienceBiofilm-disrupting antibodies for chronic joint infections
Redwood City
Jan 30, 2026
$6.1M
Embold TherapeuticsEngineered enzyme therapy for genetic Parkinson's disease
Redwood City
Jan 21, 2026
$2.5M
AirNexis TherapeuticsInhaled PDE3/4 inhibitor for COPD maintenance
Palo Alto
Jan 9, 2026
$62.0M
Dermata TherapeuticsTreatments for acne, psoriasis and rosacea
San Diego
Dec 29, 2025
$4.1M
CellanomeLive-cell imaging linked to single-cell gene expression
Foster City
Dec 23, 2025
$75.9M
Pheast TherapeuticsAntibody that blocks CD24 so macrophages attack cancer
Redwood City
Oct 7, 2025
$24.6M
ChronicleBioBiobank and data platform for Long COVID research
Menlo Park
Sep 30, 2025
$10.3M
Paralos BiosciencePhage-drug conjugates for drug-resistant infections
Los Angeles
Jul 28, 2025
$647K
Rakuten MedicalPhotoimmunotherapy drugs that target cancer cells
San Diego
Jul 11, 2025
$111.5M
Evofem BiosciencesHormone-free on-demand contraceptive gel
San Diego
Jun 26, 2025
$925K
GT BiopharmaImmune cell engagers for leukemia and other blood cancers
San Francisco
May 14, 2025
N/A
SurrozenWnt-activating antibodies for tissue repair
South San Francisco
Mar 26, 2025
$76.4M
Autonomy BioRNA therapies that activate only in cancer cells
San Francisco
Mar 17, 2025
$17.0M
Topaz BiosciencesSkin enzymes that target eczema and acne bacteria
Emeryville
Mar 11, 2025
$1.4M
BRT BiotechnologiesMacrocyclic peptide libraries for drug screening
Claremont
Mar 5, 2025
$607K
Vivace TherapeuticsHippo pathway drugs for mesothelioma and solid tumors
San Mateo
Feb 28, 2025
$17.5M
Syndex BioPioneering biotechnology company dedicated to revolutionizing…
Santa Monica
Feb 27, 2025
$15.5M
Montara TherapeuticsBrain-targeted drugs for neurological disease
San Francisco
Feb 26, 2025
$20.0M
SynlicoEngineered T cell therapies for solid tumors
South San Francisco
Feb 24, 2025
$3.0M
Maxymune TherapeuticsPioneering biopharmaceutical company focused on developing…
Los Altos
Feb 11, 2025
$2.7M
OncocyteMolecular tests for cancer and transplant care
Irvine
Feb 10, 2025
$21.7M
Resolute ScienceMacrophage-delivered drugs for solid tumors
San Diego
Feb 3, 2025
$2.9M
ChromaCodeHigh-multiplex PCR tests with cloud analysis
Carlsbad
Jan 30, 2025
$3.8M
Latigo BiotherapeuticsNon-opioid pain medicines
Thousand Oaks
Jan 28, 2025
$50.0M
Allay TherapeuticsWeeks-long local pain relief after surgery
San Jose
Jan 24, 2025
$45.0M
Celestial TherapeuticsBroad-spectrum anti-infective drug for RSV
Irvine
Sep 3, 2024
$850K
NGM BioAntibody drugs for pregnancy nausea and cancer wasting
South San Francisco
Jul 5, 2024
$142.0M
Quanta TherapeuticsOral KRAS G12D and G12V inhibitors for cancer
South San Francisco
May 10, 2023
$76.2M
RNAV8 BIOMachine learning design of mRNA for higher expression
Laguna Niguel
May 9, 2022
$2.0M
OmnioxOxygen-carrying proteins that boost radiotherapy in tumors
San Francisco
Aug 1, 2016
$24.1M
All 64 companies · most recent filing first
Most recent filings
64All 64 companies · most recent filing first